IJEP 44(14): 1301-1311 : Vol. 44 Issue. 14 (Conference 2024)
Komal Parmar* and Mehul Patel
Dharmsinh Desai University, Faculty of Pharmacy, Nadiad – 387 001, Gujarat, India
Abstract
This study focuses on the development and characterization of solid lipid nanoparticles (SLN) encapsulating sertraline hydrochloride (SH) for enhanced drug delivery. Sertraline hydrochloride, a widely prescribed antidepressant, faces challenges related to its solubility and stability. It is a significant study in the field of pharmaceutical sciences. The SLNs were produced using a modified solvent injection method with the polymer tristearin and phospholipon 90H. Various combinations of Tween 80 concentration and sonication time were employed in the SLN preparation The 32 factorial designs were used and two operating variables, sonication time and Tween 80 concentration, were found to have significant effects on particle size, entrapment efficiency and percentage drug release. Characterization techniques, such as scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), entrapment efficiency, differential scanning colourimetry and in-vitro diffusion studies, were employed. The prepared SLN were spherical in shape and possessed particles of size range 238.9-384.4 nm. The formulation F7 demonstrated the highest entrapment efficiency at 94%. The study concludes that two independent variables, surfactant concentration and sonication time, were found to significantly affect particle size, percentage entrapment efficiency and percentage drug release.
Keywords
Tristearin, Phospholipon 90H, Solid lipid nanoparticle, Entrapment efficiency, Particle size, In-vitro diffusion
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