A Critical Analysis of Covid-19 with Special Emphasis on Air Quality and its Consequences during Lockdown

IJEP 42(4): 424-431 : Vol. 42 Issue. 4 (April 2022)

Alfred J. Lawrence1, Tahmeena Khan2*, Amos Nascimento3 and Samar Fatima4

1. Isabella Thoburn College, Department of Chemistry, Lucknow- 226 007, U.P., India
2. Integral University, Department of Chemistry, Lucknow- 226 026, U.P., India
3. University of Washington, Department of Politics, Philosophy and Economics, Tacoma/Seattle, USA
4. Unity Degree College, Department of Education, Lucknow- 226 001, U.P., India


SARS-CoV-2 (Covid-19) has taken over the world. The deadly virus causes serious respiratory infections in humans. A number of research are ongoing to contain the spread of the virus. The aim of this review is to assess the impact of air pollution and environmental factors which may influence the transmission of the disease. The utilization of indigenous natural sources as remedial measures has also been explored. The studies cited in the review have been sourced from journals, books and digital media reports. The research papers indexed in databases such as PUBMED, SCOPUS and MEDLINE, etc., have been included. Evidence has suggested that the spike in air pollution may exacerbate the number of infections and the improved air quality during the lockdown period may influence the faster recovery rate. Environmental factors, like temperature, humidity and air pollution have been explored as contributing factors for the facilitated spread of the infection, or atleast in making people more vulnerable to it which makes it an issue of considerable attention in developing countries, like India, due to the high air pollution levels in megacities.


SARS-CoV-2, Medicinal, Spread, Lockdown, Air pollution, Environmental


  1. Drosten, C.S., et al. 2003. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N. Engl. J. Med., 348(20): 1967-1976.
  2. Desforges, M., et al. 2014. Neuroinvasive and neurotropic human respiratory coronaviruses: Potential neurovirulent agents in humans. Infec. Dis. Nano., 807: 75-96.
  3. Tyrrell, D.A.J., et al. 1968. Coronaviruses. Nature. 220: 650.
  4. Vincent, C.C., et al. 2007. Severe acute respiratory syndrome coronavirus as an agent of emerging and reemerging infection. Clin. Microbiol. Rev., 20(4): 660-694.
  5. Che, X.Y., et al. 2006. A patient with asymptomatic severe acute respiratory syndrome (SARS) and antigenemia from the 2003-2004 community outbreak of SARS in Guangzhou. Clin. Infect Dis., 43(1): e1-e5.
  6. Webster, R.G. 2004. Wet markets-A continuing source of severe acute respiratory syndrome and influenza? Lancet., 363(9404): 234-236.
  7. Cui, J., et al. 2019. Origin and evolution of pathogenic coronaviruses. Nat. Rev. Microbiol., 17: 181-192.
  8. Otter, J.A., et al. 2016. Transmission of SARS and MERS coronaviruses and influenza virus in healthcare settings: the possible role of dry surface contamination. J. Hosp. Infect., 92(3): 235-250.
  9. Zhou, P., et al. 2020. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 579(7798): 270-273.
  10. Shereen, M.A., et al. 2020. Covid-19 infection: Origin, transmission, and characteristics of human corona viruses. J. Adv. Res., 24: 91-98.
  11. Wu, F., et al., 2020. A new coronavirus associated with human respiratory disease in China. Nature., 579: 265-269.
  12. Li, B., et al. 2020. Discovery of bat coronaviruses through surveillance and probe capture-based next- generation sequencing. Chem. Sphere., 5(1): e00807-819.
  13. Shao, P.L., et al. 2005. Development of immunoglobulin G enzyme-linked immunosorbent assay for the serodiagnosis of severe acute respiratory syndrome. J. Biomed. Sci., 12(1): 59-64.
  14. Loon, S.C., et al. 2004. The severe acute respiratory syndrome coronavirus in tears. B. J. Ophthalmol., 88(7): 861-863.
  15. Yu, I.T., et al. 2004. Evidence of airborne transmission of the severe acute respiratory syndrome virus. N. Engl. J. Med., 350: 1731-1739.
  16. Ijaz, M.K., et al. 1985. Survival characteristics of airborne human coronavirus 229E. J. Gen. Virol., 66(12): 2743-2748.
  17. Booth, C.M., et al. 2003. Clinical features and short-term outcomes of 144 patients with SARS in the Greater Toronto area. JAMA., 289(21): 2801-2809.
  18. Yudin, M.H., et al. 2005. Severe acute respiratory syndrome in pregnancy. Obstet. Gynecol., 105(1): 124-127.
  19. Ong, K.C., et al. 2004. Pulmonary function and exercise capacity in survivors of severe acute respiratory syndrome. Eur. Respir. J., 24: 436-442.
  20. Hui, D.S., et al. 2005. The 1-year impact of severe acute respiratory syndrome on pulmonary function, exercise capacity and quality of life in a cohort of survivors. Chest., 128(4): 2247-2461.
  21. Carfì, A., et al. 2020. Persistent symptoms in patients after acute COVID-19. JAMA. 324:603–605.
  22. He, L., et al. 2020. On road emission measurements of reactive nitrogen compounds from heavy duty diesel trucks in China. Env. Poll., 262: 114280.
  23. Dutheil, F., et al. 2020. Covid-19 as a factor influencing air pollution. Env. Poll., 263.
  24. Cui, Y., et al. 2003. Air pollution and case fatality of SARS in the People’s Republic of China: An ecologic study. Env Hea: A Global Acc. Sci. Sou., 20(2): 15.
  25. Rodríguez-Urrego, D., et al. 2020. Air quality during the COVID-19: PM2.5 analysis in the 50 most polluted capital cities in the world. Env. Poll., 266:115052. DOI: 10.1016/j.envpol.2020.115042
  26. Zhao, H., et al. 2019. Inequality of household consumption and air pollution-related deaths in China. Nat. Commun.,10:4337.
  27. Cai, G., et al. 2020. A hint on the Covid-19 risk: Population disparities in gene expression of three receptors of SARS-CoV. Preprints. 2020020408.
  28. Mishra, S., et al. 2016. Trends in bidi and cigarette smoking in India from 1998 to 2015, by age, gender and education. BMJ Glob. Health. 1(1): e000005.
  29. Jindal, S.K., et al. 2006. Asthma epidemiology study group. A multicentric study on epidemiology of chronic obstructive pulmonary disease and its relationship with tobacco smoking and environmental tobacco smoke exposure. Indian J. Chest Dis. Allied Sci., 48(1): 23-29.
  30. Zhu, P., et al. 2021. The role of high-speed rail and air travel in the spread of COVID-19 in China. Travel Med. Infect. Dis., 42:102097.
  31. Künzli, N., L. Perez and R. Rapp. 2010. Air quality and health. European respiratory society, Lausanne (Switzerland).
  32. Esposito, S., et al. 2014. Impact of air pollution on respiratory diseases in children with recurrent wheezing or asthma. BMC Pulm. Med., 14: 130.
  33. Medina-Ramón, M., et al. 2006. The effect of ozone and PM10on hospital admissions for pneumonia and chronic obstructive pulmonary disease: A national multicity study. Am. J. Epidemiol., 163(6): 579-586.
  34. Zhu, Y., et al. 2020. Association between short-term exposure to air pollution and covid-19 infection: Evidence from China. Sci. Total Env., 727: 138704.
  35. Leni, Z., et al. 2020. Air pollution causing oxidative stress. Curr. Opi. Toxicol., 20-21:1-8.
  36. Balakrishnan, K., et al. 2019. The impact of air pollution on deaths, disease burden and life expectancy across the states of India: The global burden of disease study 2017. Lancet Planetary Health. 3(1):E26-E39.
  37. Yin, P., et al. 2020. The effect of air pollution on deaths, disease burden and life expectancy across China and its provinces 1990–2017: An analysis for the global burden of disease Study 2017. Lancet Planetary Health. 4(9):E386-E398.
  38. Copat, C., et al. 2020. The role of air pollution (PM and NO2) in COVID-19 spread and lethality: A systematic review. Env. Res., 191:110129.
  39. Sedlmaier, N., et al. 2009. Generation of avian influenza virus (AIV) contaminated fecal fine particulate matter (PM2.5): Genome and infectivity detection and calculation of immission. Vet. Micro., 139(1-2): 156-164.
  40. Setti, L., et al. 2020. SARS-Cov-2 RNA found on particulate matter of Bergamo in Northern Italy: First preliminary evidence. Env. Res., 188: 109754.
  41. Dantas, G., et al. 2020. The impact of covid-19 partial lockdown on the air quality of the city of Rio de Janerio, Brazil. Sci. Total Env., 729: 139085.
  42. Nakada, L.Y.K., et al. 2020. Covid-19 pandemic: Impacts on the air quality during the partial lockdown in Sao Paulo state, Brazil. Sci. Total Env., 730: 139087.
  43. Sharma, S., et al. 2020. Effects of restricted emissions during covid-19 on air quality in India. Sci. Total Env., 728: 138878.
  44. WHO. 2016. WHO global urban ambient air pollution database.
  45. WHO. 2018. State of global air: A special report on global exposure to air pollution and its disease Brden. Health Effects Institute, The Institute for Health Metrics and Evaluation, University of British Columbia, Boston.
  46. Kumar, P., et al. 2017. The influence of odd-even car trial on fine and coarse particles in Delhi. Env. Poll., 225, 20-30.
  47. Chowdhury, S., et al. 2019. Indian annual ambient air quality standard is achievable by completely mitigating emissions from household sources. Proc. Natl. Acad. Sci., 116(22): 10711-10716.
  48. Chauhan, A. and R.P. Singh. 2020. Decline in PM2.5concentrations over major cities around the world associated with covid-19. Env. Res., 187: 109634.
  49. Mahato, S., et al. 2020. Effect of lockdown amid covid-19 pandemic on air quality of the megacity Delhi. Sci. Total Env., 730: 139086.
  50. Gautam, S. 2020. Covid-19: Air pollution remains low as people stay at home. Air Quality Atm. Health., 13: 853-857.
  51. Government of India, Ministry of Environment, Forest and Climate Change. 2019. Government launches National Clean Air Programme (NCAP). Available at https://pib.gov.in/ newsite/PrintRelease.aspx?relid= 187400.
  52. Avendano, M.P., et al. 2003. Clinical course and management of SARS in health care workers in Toronto: A case series. CMAJ., 168 (13): 1649-1660.
  53. Ma, Y., et al. 2020. Effects of temperature variation and humidity on the death of covid-19 in Wuhan, China. Sci. Total Env., 724: 138226.
  54. Jahangiri, M., et al. 2020. The sensitivity and specificity analyses of ambient temperature and population size on the transmission rate of the novel coronavirus (Covid-19) in different provinces of Iran. Sci. Total Env., 728: 138872.
  55. Sultan, M.T., et al. 2014. Immunity: Plants as effective mediators. Crit. Rev. Food Sci. Nutr., 54 (10): 1298-1308.
  56. Troesch, B., et al. 2012. Dietary surveys indicate vitamin intakes below recommendations are common in representative western countries. B. J. Nutr., 108(4): 692-698.
  57. Dias, D.A., et al. 2012. A historical overview of natural products in drug discovery. Metabol., 2(2): 303-336.
  58. Mogensen, T.H. 2009. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin. Microbiol. Rev., 22(2): 240-273.